Registration Dossier
Registration Dossier
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EC number: 217-157-8 | CAS number: 1758-73-2
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is unstable under alkaline conditions.
Key value for chemical safety assessment
Additional information
No experimental data according to accepted guidelines are
available for this endpoint. In accordance with Regulation (EC) No
1907/2006, Annex VIII, 9.2.2.1., column 2 testing is not required since
aminoiminomethanesulphinic acid (CAS No. 1758-73-2) is readily
biodegradable. However, data from literature indicate that the substance
is unstable under alkaline conditions. Miller et al. (1988) investigated
the stability of aminoiminomethanesulphinic acid in buffer solutions at
pH 7.4, pH 10 and pH 13-14 for 24 h. Urea and cyanamide were identified
as primary degradation products. After 24 h 5% formation of urea was
recorded at pH 7.4, whereas 35% formation of urea and 5% of cyanamide
was measured at pH 10. At pH 13 85% formation of urea was found.
Svarovsky et al. (2001) studied the kinetics and mechanism of
decomposition of thioureas in alkaline solutions. The decomposition of
thiourea dioxide is characterized by an induction period which is
followed by the formation of dithionite (S2O4 2-) under aerobic
conditions.The initial step of decomposition is the cleavage of the C-S
bond to give an urea residue and the sulfoxylate ion, SO2-, which is the
precursor to the formation of dithionite vial a rapid equilibrium. In
aerobic environments the sulfoxylate ion can produce the highly
tissue-damaging series of reactive oxygen species superoxide, peroxide,
and hydroxyl radical. These species could be responsible for the
inherent toxicities associated with thioureas.
An additional study which is available only as a short summary,
indicated that an aqueous solution of aminoiminomethanesulphinic acid is
unstable under aerobic conditions at 20 °C (OECD, 2002). 30% of the
substance were degraded after 22 h.
All available data indicate that aminoiminomethanesulphinic acid is
unstable under alkaline conditions leading to the formation of urea.
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