Registration Dossier
Registration Dossier
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EC number: 263-171-2 | CAS number: 61791-39-7
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
The 10 day LC50 was estimated to be 661 mg/kg dry sediment as determined by the Maximum Likelihood-Probit Method. The highest no-observed effect concentration (NOEC) was estimated as 306 mg/kg dry sediment. The lowest observed effect (LOEC) was 766 mg/kg dry sediment.
Key value for chemical safety assessment
- EC50 or LC50 for marine water sediment:
- 661 mg/kg sediment dw
- EC10, LC10 or NOEC for marine water sediment:
- 306 mg/kg sediment dw
Additional information
The objective of the study was to determine the toxicity of test substance PR-9061 to the sediment organism Corophium sp.The test was carried out according to the SOP E211 based on Paris Commission Guidelines 1994 "A sediment bioassay using an amphipod Corophium sp.". Test animals were exposed to various concentrations of test item PR-9061 under constant conditions. The mortality in relation to control was determined over a test period of 10 days. The definitive test was performed with use of 6 concetrations: 0 (control), 256, 640, 1600, 4000 and 10000 mg/kg wet sediment. Two replicates of 10 animals per concentration were used. Records were made of the number on animals observed alive and dead on the surface of the sediment.
The highest no-observed effect concentration (NOEC) was estimated as 306 mg/kg dry sediment. The lowest observed effect (LOEC) was 766 mg/kg dry sediment. The LC50 was estimated to be 661 mg/kg dry sediment as determined by the Maximum Likelihood-Probit Method.
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