2-phenylpropionaldehyde-dimethyl acetal

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Minimal experimental detail and documentation. Information available in a summary document only. Although studies were not conducted according to currently accepted protocols and did not follow GLP procedures, the studies followed acceptable procedures of the time and the results are valid.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-phenylpropionaldehyde-dimethyl acetal

EC Number:

202-022-8

EC Name:

2-phenylpropionaldehyde-dimethyl acetal

Cas Number:

90-87-9

Molecular formula:

C11H16O2

IUPAC Name:

(1,1-dimethoxypropan-2-yl)benzene

Test material form:

liquid

Test animals

Species:

rat

Administration / exposure

Route of administration:

oral: unspecified

Doses:

670, 1310, 2560, and 5000 mg/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Examinations performed: clinical signs

Results and discussion

Effect levels

Key result

Dose descriptor:

LD50

Effect level:

1 850 mg/kg bw

Based on:

test mat.

95% CL:

>= 1 270 - <= 2 430

Mortality:

At 670 mg/kg bw no mortality was observed. In the 1310, 2560, and 5000 mg/kg bw dose groups, 1, 8, and 10 animals died, respectively. All animals that died, died on day 1.

Clinical signs:

other: At 670 mg/kg bw no clinical signs were observed. Animals of the 1310 mg/kg bw dose group showed lethargy and labored breathing. Animals of the 2560 mg/kg bw dose group showed labored breathing, loss of righting reflex and coma. Coma was observed in animal

Applicant's summary and conclusion

Interpretation of results:

other: Acute Tox. Category 4

Remarks:

according to EU CLP Regulation (EC) No. 1272/2008 and its amendments.

Conclusions:

The acute oral toxicity test showed an LD50 of 1850 mg/kg bw.

Executive summary:

In an acute oral toxicity study performed similar to OECD 401 (pre-OECD and GLP), 10 rats were administered the test substance orally at dose levels of 670, 1310, 2560 or 5000 mg/kg bw. The animals were observed for mortality and clinical signs for 14 days. Mortality was observed at the three highest dose levels. One, eight and ten animals died, all on the first day, in the dose groups 1310, 2560, and 5000 mg/kg bw, respectively. Clinical signs included lethargy, labored breathing, loss of righting reflex and coma. The acute oral LD50 for the test substance in rats was determined to be 1850 mg/kg bw.