Registration Dossier
Registration Dossier
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EC number: 215-245-0 | CAS number: 1314-85-8
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- other: expert judgement
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data derived from expert judgement.
Data source
Reference
- Reference Type:
- other: expert judgement.
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
- Principles of method if other than guideline:
- Expert judgement
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetraphosphorus trisulphide
- EC Number:
- 215-245-0
- EC Name:
- Tetraphosphorus trisulphide
- Cas Number:
- 1314-85-8
- Molecular formula:
- P4S3
- IUPAC Name:
- 3,5,7-trithia-1,2,4,6-tetraphosphatricyclo[2.2.1.0²,⁶]heptane
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 1 mg/kg bw/day (nominal)
- Remarks on result:
- other: RA based on expert judgement.
Target system / organ toxicity (P0)
- Critical effects observed:
- no
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- ca. 1 mg/kg bw/day (nominal)
- Remarks on result:
- other: RA based on expert judgement.
Target system / organ toxicity (F1)
- Key result
- Critical effects observed:
- no
Overall reproductive toxicity
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- Estimated NOAEL (reproductive toxicity)= 1 mg/kg bw/day based on the results of preliminary OECD TG 422.
- Executive summary:
Estimated NOAEL (reproductive toxicity)= 1 mg/kg bw/day based on the results of preliminary OECD TG 422.
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