Registration Dossier
Registration Dossier
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EC number: 309-264-4 | CAS number: 100208-62-6
Endpoint summary
Administrative data
Description of key information
Not irritating to skin, not irritating to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The test item,was assayed for in vitro skin irritation in the human epidermal model EpiDermTM according tot he OECD Test Guideline No.439.
After pre-incubation of tissues, 25 mg of the test item was placed directly on tissue and spread on the entire tissuesurface.The length of exposure was 60 minutes. Three tissues were used for the test item and for positive and negative controls.After removal of the test item, tissues were post-incubated for approximately 42 hours. Three hours incubation with MTT and two hours extraction period with shaking followed. Optical density (OD570) of isopropyl alcohol extracts was measured on a spectrophotometer. Relative cell viability was calculated for each tissue as % of the mean viability of the negative control tissues.
Tests for colour interference and direct reduction did not demonstrate influence of colour or reductive properties of the test substance on study results.Thus, no steps for correction of results were performed.
Under the above-described experimental design,average viability of treated tissues was 89.6%,i.e. viability was >50 %.
The effect of the test item was negative in EpiDermTMmodel (tissues were not damaged).
According to the classification criteria,the test item ,is considered to have no category with regard to skin irritation.
Justification for classification or non-classification
Based on the available information, the substance is expected to be not classified for skin irritation/corrosion and eye irritation according to the CLP Regulation (EC. 1272/2008).
No adverse effect observed in tests conducted for skin irritation/corrosion and eye irritation.
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