2-methyl-2H-isothiazol-3-one

Storage stability and reactivity towards container material

Administrative data

Endpoint:

storage stability and reactivity towards container material

Type of information:

experimental study

Adequacy of study:

key study

Study period:

February - July 1995

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was not conducted according to guidelines but was conducted according to GLPs and the report contains sufficient data for interpretation of study results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1995

Report date:

1995

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Two samples of the same lot number of Kordek 573T Industrial Microbiocide were submitted for analysis at zero time, one month and three month time points.

GLP compliance:

yes

Type of method:

ambient testing

Test material

Test material information

Constituent 1

Test material form:

other: solid

Details on test material:

All Series 63 characterizations of Kordek 573T Industrial Microbicide were done using the Technical Grade Active Ingredient (TGAI). The test material consisted of >95% 2-methyl-4-isothiazol-3-one. Impurities ranged from 0.1 to 1.0% and total less than 5.0%.

Specific details on test material used for the study:

All samples were prepared in a glove box that was purged with nitrogen (relative humidity was <10%). Each sample was melted, and aliquots were transferred into dry, preweighed vials. The sample weight was determined by difference.

The working standard used is RH-573, Lot AAP12269C, 48.7% in Propylene Glycol. The control sample used was Batch 1935 from Technical Grade Lot # 1022 = 51.8%. The samples were prepared in duplicate and each prep was injected in duplicate. The control sample was prepped in duplicate and the preps were analyzed twice, distributed throughout the sequence.

Results and discussion

Results:

The test material was stable over a 3 month time period. There was no change in color and physical state of the test material over the three months. In addition, there was no change in the storage container over the three month period.

Transformation products:

no

Any other information on results incl. tables

Table 1 Grand Averages for % 573 Samples (Sample #1029)

Age	% RH-573
Zero Time	96.8
One Month	97.1
Three Month	98.4

Applicant's summary and conclusion

Conclusions:

Kordek 573T Industrial Microbiocide was stable for at least 3 months.

Executive summary:

The stability of Kordek 573T Industrial Microbicide was determined over a three month period. Kordek 573T Industrial Microbiocide was stable for at least 3 months.