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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
REPORTS of the Scientific Committee on Cosmetology (seventh series)
Author:
Published by the COMMISSION OF THE EUROPEAN COMMUNITIES; Directorate-General Telecommunications, Information Industries and Innovation
Year:
1988
Bibliographic source:
Scientific Committee on Cosmetology (seventh series),1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To determine the eye irritation potential of the test chemical in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 4(-2-hydroxy-1-naphthylazo)naphthalenesulphonate
EC Number:
216-760-3
EC Name:
Sodium 4(-2-hydroxy-1-naphthylazo)naphthalenesulphonate
Cas Number:
1658-56-6
Molecular formula:
C20H14N2O4S.Na
IUPAC Name:
Sodium 4-[(E)-2-(2-hydroxynaphthalen-1-yl)diazen-1-yl]naphthalene-1-sulfonate
Test material form:
solid: particulate/powder
Details on test material:
Name of the test chemical:Sodium 4-[(E)-2-(2-hydroxynaphthalen-1-yl)diazen-1-yl]naphthalene-1-sulfonateMolecular formula: C20H13N2NaO4SMolecular Weight: 400.4 g/molSMILES Notation: c12c(c(ccc1\N=N\c1c3c(ccc1O)cccc3)S(=O)(=O)[O-])cccc2.[Na+]Substance Type: OrganicPhysical State: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
100 µl
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
TEST SITE- Area of exposure: conjunctival sac

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No signs of irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
No signs of irritation were observed when rabbits were exposed to the test chemical. The test chemical can be considered to be not irritating to rabbit eyes.
Executive summary:

The eye irritation potential of the test chemical was assessed in rabbits. 100 µl of undiluted test chemical was instilled in the eyes of rabbits and observed for signs of irritation(duration of exposure not mentioned).No signs of irritation were observed. Hence, the test chemical can be considered to be not irritating to rabbit eyes.