2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30-03-2018 – 03-04-2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

The water solubility determination of test item 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203-90-3) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101.

GLP compliance:

no

Type of method:

other: spectrophotometric analytical method

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated- IUPAC name: 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl) azo] phenyl] azo]-, ar-styrenated- Molecular formula: C40H36N4O1 - Molecular wt. : 588.76 g/mole- smiles : Cc1ccccc1N=Nc2ccc(c(C)c2)N=Nc3c4ccc(C(C)c5ccccc5)cc4cc(C(C)c6ccccc6)c3O- Substance type: Organic- Physical state: red liquid

Key result

Water solubility:

0.141 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

Remarks on result:

other: no other details mentioned

WATER SOLUBILITY: PRELIMINARY TEST

0.1g of test item was taken in 100 ml beaker. DI water was added in increasing amount in sequence of 0.1 ml, 0.5 ml, 1.0 ml,

2.0 ml, 10.0 ml and 100.0 ml with intermediate stirring.

For poorly soluble substances: Preliminary water solubility of test item was found 0.1g in > 100 ml DI water. For analytical determination 100 mg of test item was dissolved in 100 ml of DI water. The solution was kept for 96 hrs on stirring and absorbance was recorded. Concentration detected on the basis of standard curve was 0.2152 mg/L. Five times the concentration recorded from preliminary solubility was used for confirmatory study.

WATER SOLUBILITY: CONFIRMATORY TEST

Five times the concentration recorded from preliminary solubility = 0.2152 mg/L × 5 = 1.076 mg/L was used for confirmatory study. Two separate solution of 1.076 mg in 100 ml DI water were prepared and kept for stirring for 48 hrs and 72 hrs. After the completion of stirring period the absorbance for all the two solution were recorded and concentration was detected on the basis of standard curve. Table 2 refers to the same.

Sample stirring	Concentration obtained on the basis of standard curve	Dilution factor	Solubility value obtained (mg/L)
24 hour	-	-	-
48 hour	0.1312	-	0.1312
72 hour	0.1503	-	0.1503

 

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows: Mean water solubility value for 48 hour run sample + 72 hour run sample

=(0.1312+0.1503)2

=0.14075 mgL

Conclusions:

The water solubility for the test item 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated was found to be 0.14075 mgL at 25°C.

Executive summary:

The water solubility determination of test item 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203-90-3) was done as per the OECD guideline 105 byspectrophotometric analytical method as per OECD 101.

The solubility of (2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated of CAS No: 85203-90-3) in water was found to be 0.14075 mgL at 25°C.

Hence, the given compound is considered to be slightly soluble in water.

Description of key information

The water solubility for the test item 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated was found to be 0.14075 mgL at 25°C.

Key value for chemical safety assessment

Water solubility:

0 mg/L

at the temperature of:

25 °C

Additional information

The water solubility determination of test item 2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated (CAS No. 85203-90-3) was done as per the OECD guideline 105 byspectrophotometric analytical method as per OECD 101.

The solubility of (2-Naphthalenol, 1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]-, ar-styrenated of CAS No: 85203-90-3) in water was found to be 0.14075 mgL at 25°C.

Hence, the given compound is considered to be slightly soluble in water.