Registration Dossier
Registration Dossier
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EC number: 201-155-9 | CAS number: 78-90-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
1,2-propanediamine is with high probability acutely not harmful to algae. Long-term effects are not to be expected.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 98 mg/L
- EC10 or NOEC for freshwater algae:
- 9.4 mg/L
Additional information
Experimental data are available on the toxicity of 1,2-propanediamine (CAS 78-90-0) to freshwater algae. An algal Inhibition test was performed according to EU Method C.3. The 72-h ErC50 the substance was determined to be 68 mg/L and the NOEC was found to be 9.4 mg/L (nom., Bayer AG, 1992). No analytical verification was performed during the study. However, it is assumed that the test concentrations remained stable over the exposure period based on a sufficient water solubility, a low Henry's Law constant and a low adsorption potential (log Kow and log Koc < 3). The result is supported with the calculation performed with QSAR Toolbox v4.4. The 72 -h EC50 was determined to be 202 mg/L (BASF SE, 2021). The 72-h EC10 was determined to be 22.2 mg/L (BASF SE, 2021). The substance was within the applicability domain of the model. Both values were calculated with the Trend analysis method and the substance was within the applicability domain of calculation models.
Overall, it can be concluded, that that 1,2-propanediamine is with high probability acutely harmful to algae. Long-term effects are not to be expected.
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