Registration Dossier
Registration Dossier
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EC number: 201-155-9 | CAS number: 78-90-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: internal human data research based on data from BASF's ambulance
- Adequacy of study:
- weight of evidence
- Study period:
- 1991 - 2018
- Reliability:
- other: not applicable, internal human data research based on clinical cases/ poisoning incidents at BASF
- Rationale for reliability incl. deficiencies:
- other: not applicable
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- acute toxicity: dermal
- skin irritation / corrosion
- respiratory irritation
- skin sensitisation
- respiratory sensitisation
- Principles of method if other than guideline:
- Company-internal observations of poisoning incidents of workers.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propylenediamine
- EC Number:
- 201-155-9
- EC Name:
- Propylenediamine
- Cas Number:
- 78-90-0
- Molecular formula:
- C3H10N2
- IUPAC Name:
- propane-1,2-diamine
- Details on test material:
- - Name of test material: 1,2-propandiamine
- Analytical purity: pure substance
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 17
- Route of exposure:
- dermal
- inhalation
- Reason of exposure:
- unintentional, occupational
Results and discussion
- Clinical signs:
- 17 cases of skin irritation with varying degrees of expression were reported from the plants ambulance (1991 - 2018) after acute local contact to the test substance during occupational handling. 4 of these workers were intoduced to an accident insurance consultant.
Applicant's summary and conclusion
- Conclusions:
- 17 cases of acute, incidential contact to the test substance during occupational handling were reported by the plants ambulance (from 1991 to 2018). For all 17 cases skin irritation with varying degrees of expression were reported. Four of these workers were introduced to an accident insurance consultant. None of the 17 cases showed signs for skin or respiratory sensitisation.
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