Registration Dossier
Registration Dossier
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EC number: 946-398-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Abiotic degradation; Hydrolysis
The test item has been shown to be readily biodegradable and, in accordance with REACH Annex VIII, Section 9.2.2.1, Column 2, it is not necessary to investigate hydrolysis as a function of pH.
Biodegradation
A key study was performed to assess the ready biodegradability of the test item in an aerobic aqueous medium. The method was designed to be compatible with OECD Guidelines for Testing of Chemicals (1992) No 301B "Ready Biodegradability; CO2 Evolution Test" referenced as Method C.4 -C of Commission Regulation (EC) No 440/2008 and US EPA Fate, Transport, and Transformation Test Guidelines OCSPP 835.3110 (Paragraph m).
The test item at a concentration of 10 mg carbon/L was exposed to activated sewage sludge micro-organisms with mineral medium in sealed culture vessels in the dark at temperatures between 21 and 24 °C for 28 days.
The biodegradation of the test item was assessed by determination of carbon dioxide produced. Control solutions with inoculum and the reference item, sodium benzoate, and a toxicity control were used for validation purposes.
The test item attained 74 % biodegradation after 28 days and satisfied the 10 -day window validation criterion, whereby 60% biodegradation must be attained within 10 days of the biodegradation exceeding 10%. The test item can therefore be considered to be readily biodegradable under the strict terms and conditions of OECD Guideline 301 B.
The toxicity control attained 77 % biodegradation after 14 days and 108 % biodegradation after 28 days thereby confirming that the test item did not exhibit an inhibitory effect on the sewage treatment microorganisms used in the test. Biodegradation values in excess of 100 % were considered to be due to sampling/analytical variation.
Sodium benzoate attained 80 % biodegradation after 14 days and 77 % biodegradation after 28 days thereby confirming the suitability of the inoculum and test conditions. The slight decrease in biodegradation between days 14 and 28 was considered to be due to sampling/analytical variation.
Adsorption / desorption coefficient (Koc)
Adsorption coefficient was determined using the HPLC screening method designed to be compatible with Method C.19 of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
The test utilised a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The adsorption coefficient of the test item was found to be in the range 5.71 x 10E-04 to > 4.27 x 10E+05 with Log10 Koc 4.76 to > 5.63.
Additional information
No additional data.
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