Registration Dossier
Registration Dossier
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EC number: 203-636-9 | CAS number: 108-99-6
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case reports
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Anecdotal reports of effects of exposure of methyl pyridines.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- 3-Methylpyridine: Human toxicity excerpts
- Author:
- Anonymous
- Year:
- 2 010
- Bibliographic source:
- Hazardous Substances Data Base(HSDB), ToxNet, http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rYtOpf:1
Materials and methods
- Study type:
- other: case reports
- Endpoint addressed:
- not applicable
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- case reports of exposures
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methylpyridine
- EC Number:
- 203-636-9
- EC Name:
- 3-methylpyridine
- Cas Number:
- 108-99-6
- Molecular formula:
- C6H7N
- IUPAC Name:
- 3-methylpyridine
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
Any other information on results incl. tables
3-METHYLPYRIDINE
CASRN: 108-99-6
Human Toxicity Excerpts:
CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF
PYRIDINE INCL WT LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS.
/PICOLINES/
POISONING IN 32 YR OLD MALE INDUST EXPOSED TO VAPORS WAS CHARACTERIZED
BY AUTONOMIC DISTURBANCES AGAINST ASTHENIC BACKGROUND (ANGIODYSTONIA,
TENDENCY TOWARD HYPOTONIA & BRADYCARDIA, INCR OF PILOMOTOR REFLEX, &
DISTURBANCES OF THERMOREGULATION) & BY POLYNEURITIC PHENOMENA.
A 58 YR OLD MAN OCCUPATIONALLY EXPOSED TO BETA-PICOLINE FOR 11 YR SHOWED
AN INCR IN LIVER GLUTAMIC PYRUVIC TRANSAMINASE & GLUTAMIC OXALACETIC
TRANSAMINASE.
Exposures to the picolines may give rise to flushing of the face, skin
rash, an increase in heart and respiration rates, headache, giddiness,
nausea and vomiting. /Picolines/
ALKYL DERIVATIVES, PICOLINES ... CAUSE SYMPTOMS RESEMBLING THOSE
OBSERVED WITH PYRIDINE. THESE ARE LARGELY NONSPECIFIC & INCL WEAKNESS,
ATAXIA, DIARRHEA, & UNCONSCIOUSNESS. DELAYED DEATHS FOLLOWING SINGLE
DOSE ARE UNCOMMON & SURVIVORS GENERALLY GAIN WT NORMALLY. /PICOLINES/
Applicant's summary and conclusion
- Conclusions:
- CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIV OF PYRIDINE INCLUDE WEIGHT LOSS, DIARRHEA, WEAKNESS, ATAXIA & UNCONSCIOUSNESS.
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