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EC number: -
CAS number: -
In the dose-finding test and the main test,
neither an increase in the number of revenant colonies (more than twice
as many as that of the negative control) nor a dose-related response was
observed at any doses in any strains of base-pair substitution type or
frame-shift type, with or without metabolic activation.
The revertant colonies of the positive
controls showed an increase of more than twice that of the negative
controls and they were within limit of controls (mean ± 3SD) in
background data, indicating that this study was performed correctly.
From these results, mutagenicity of the test
substance was judged negative.
The growth inhibition of the test strains by
the test substance was not observed. and the precipitate on the plates
was not observed either with or without metabolic activation.
In the sterility test on the test solution
and the S9 mix, no growth of bacteria was observed.
1) B.N. Ames, F.D. Lee, and W.E. Durston: An
Improved Bacterial Test System for the Detection and Classification of
Mutagens and Carcinogens, Proc. Natl. Acad. Sci. USA Vo1.70,
No.3, pp.782-786, March 1973
2) J. McCann, N. E. Spingarn, J. Kobori and
B.N. Ames: Detection of Carcinogens as Mutagens: Bacterial Tester
Strains with R Factor Plasmids, Proc. Natl. Acad. Sci. USA Vol.72,
No.3, pp.979-983, March 1975
3) M.H.L. Green and W.J. Muriel: Mutagen
Testing using Trp+ Reversion in Escherichia coli, Mutation Res.
Vol.38, pp.3-32. 1976
4) T. Yahagi, M. Nagao, Y. Seino.
T.Matsushima. T.Sugimura and M.Okada: Mutagenicities of N-nitrosamines
on Salmonella, Mutation Res. Vol.38, pp.121-130,
5) D.Maron and B.N. Ames: Revised Methods
for the Salmonella Mutagenicity Test, Mutalion Res. Vol.l13,
6) A guidebook for Mutagenicity Studies
using Bacteria, New Edition, Ed. by Chemical Substances Investigation
Division, Industrial Safety and Health Department, Ministry of Labor,
Japan Industrial Safety and Health Association, 1986
7) Testing Methods for Environmental
Mutagens: Ed. by Tajima, Kada, Kondo and Tamura, Koudan-sha Co.,
Mutagenicity potential of H-Ml was assessed
with Salmonella typhimurium TA 100, TA 1535, TA98, TA 1537 and Escherichia
coli WP2 uvrA. In this study, neither an increase in the
number of revertant colonies more than twice in comparison with that of
the negative control nor a dose-related response was observed in any
strains of base-pair substitution type or frame-shift type, with or
without metabolic activalion.
From the above, it is judged H-MI has no
mutagenicity to bacteria under the described study conditions.
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