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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Skin irritation potential of test chemical
Author:
U.S. National Library of Medicine
Year:
2020
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine, 2020
Reference Type:
review article or handbook
Title:
Skin irritation potential of test chemical
Author:
Opdyke, D.L.J.
Year:
1979
Bibliographic source:
Monographs on Fragrance Raw Materials, 1979
Reference Type:
review article or handbook
Title:
Skin irritation potential of test chemical
Author:
Raymond M et. al.
Year:
2001
Bibliographic source:
Handbook of Environmental Data on Organic Chemicals, 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Determination of skin irritation potential of test chemical on Rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl o-aminobenzoate
Cas Number:
134-20-3
Molecular formula:
C8H9NO2
IUPAC Name:
Methyl o-aminobenzoate
Test material form:
liquid
Details on test material:
IUPAC name: 2-Aminobenzoic acid, methyl ester
Mol. formula: C8H9NO2
Molecular Weight: 151.1641 gm/mol
Smiles: c1(c(cccc1)N)C(OC)=O
InChI: 1S/C8H9NO2/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5H,9H2,1H3

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100% of the test chemical
Duration of treatment / exposure:
24 hours
Observation period:
not specified
Number of animals:
not specified
Details on study design:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
not specified
Other effects:
Moderate irritating effects observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Skin irritation study was performed on rabbits. Moderate irritating effects were observed indicating that the test chemical can be cotegorized as Category 2 (irritant) based on GHS criteria.
Executive summary:

Skin irritation study was performed on rabbits to deteremine the irritating effects of test chemical. The test chemical was applied full strength to intact or abraded rabbit skin for 24 hr under occlusion. Moderate irritating effects were observed indicating that the test chemical can be cotegorized as Category 2 (irritant) based on GHS criteria.