Registration Dossier
Registration Dossier
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EC number: 211-976-4 | CAS number: 728-88-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4'-dimethyl-3-piperidinopropiophenone hydrochloride
- EC Number:
- 222-876-5
- EC Name:
- 2,4'-dimethyl-3-piperidinopropiophenone hydrochloride
- Cas Number:
- 3644-61-9
- Molecular formula:
- C16H23NO.HCl
- IUPAC Name:
- 1-[2-methyl-3-(4-methylphenyl)-3-oxopropyl]piperidinium chloride
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Amount / concentration applied:
- The test material was given in a single dose of 0.5g/animal with a 4-hour exposure on the intact hairless skin.
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 day
Results and discussion
In vivo
Results
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation symptoms (erythema or edema) or other changes were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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