Registration Dossier
Registration Dossier
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EC number: 214-507-1 | CAS number: 1137-42-4
Endpoint summary
Administrative data
Description of key information
Oral rat: LD50 12086 mg/kg
Behavioral: Somnolence (general depressed activity), Convulsions or effect on seizure threshold; Lungs, thorax or respiration: dyspnea (18-20 Vadkovskii per. Moscow, 101479, Russia; History Unknown (2), 25, 1994)
Oral mouse: LD50 3724 mg/kg
Behavioral: somnolence (general depressed activity), convulsions or effect on seizure threshold; Lungs, thorax or respiration: Dyspnea (18-20 Vadkovskii per. Moscow, 101479, Russia; History Unknown (2), 25, 1994)
Inhalation rat: TCLo 41.4 mg/m³/4H
Kidney, Ureter and bladder: other changes in urine composition; blood: changes in serum composition (e.g. TP, bilirubin, cholesterol; Biochemical: Enzyme inhibition, induction or change in blood tissue levels, Phosphatases)
(18-20 Vadkovskii per. Moscow, 101479, Russia; History Unknown (2), 25, 1994)
Read-across data captured from published Benzophenone registration dossier:
Oral mouse (OECD Guideline 401): LD50 ca. 2895 mg/kg bw (Caprino L et al., 1975, Eur J Toxicol Environ Hyg 9, 99-103)
Dermal rabbit (no guideline followed): LD50 3535 mg/kg bw (Opdyke DLJ, 1979, Food Cosmet Toxicol 11, 873-874)
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test and read-across data is reliable and suitable for classification purposes under Regulation (EC) No 1272/2008, as amended for the seventh time in Regulation (EC) No 2015/1221. As a result the substance is considered to be not classified for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
