calcium N2,N6-bis(3-carboxypropanoyl)lysine (1:1)

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

March from 03rd to 06th, 2009

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

although the results are out of the applicability domain of the test method, the study outcomes can be considered representative for the tested substance

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Version / remarks:

July, 1995

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient)

GLP compliance:

yes

Remarks:

temporary certificate

Type of method:

flask method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

< -2.9

Temp.:

22 °C

pH:

5

Type:

Pow

Partition coefficient:

< 0.001

Temp.:

22 °C

pH:

5

Details on results:

The experimental data showed a completely test article solubility in the aqueous phase and no repartition in the n-octanol phase was observed.
The n-octanol solubility can be estimated to be lower than 2.5 mg/l ( L.O.D. Limit of Detection of the analytical phase).

ln presence of both water and n-octanol phases, considering the difference between the two solubilities, the test article should be dissolved principally in the water phase and the concentration in the organic phase should be lower than the limit of detection value.
Therefore it can be estimated that the partition coefficient between n-octanol and water should be lower than the ratio between the two solubilities.

Partition coefficient test (aqueous phases).

Solution	As	Cs (1) (µg/ml)	D	Substance surrogate (µg/ml)
Mother solution	399946	19.93	100	1993.23
Water o:w = 1:1 A	395165	19.7	100	1970.21
Water o:w = 1:1 B	392480	19.57	100	1957.28
Water o:w = 1:2 A	399837	19.93	100	1992.7
Water o:w = 1:2 B	394563	19.67	100	1967.31
Water o:w = 2:1 A	396643	19.77	100	1977.33
Water o:w = 2:1 B	398714	19.87	100	1987.30

Conclusions:

logPow = -2.9 at 22 °C and pH 5

Executive summary:

The test was conducted according to the OECD Guideline 107 by means of the flask method.

The Partition coefficient results to be logPow = -2.9 at 22 °C and pH = 5.

Description of key information

-2.9 at 22.0 °C and pH 5 (Pow < 0.00125)

Key value for chemical safety assessment

Log Kow (Log Pow):

-2.9

at the temperature of:

22 °C

Additional information

EU method A.8