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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
The Aspiration Hazard and Toxicity of a Homologous Series of Alcohols.
Author:
Gerare, H. and Ahlstrom, D.
Year:
1966
Bibliographic source:
Arch. Environ.|Health, Vol. 13, October, 1966.
Reference Type:
review article or handbook
Title:
Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York:
Author:
Clayton, G. D. and F. E. Clayton (eds.).
Year:
1981
Bibliographic source:
John Wiley Sons, 1981-1982., p. 4610

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method other: lethality by aspiration
Animals were induced to aspirate the test substance placing 0.2 ml of the test substance into the mouth and then closing the nostrils during inspiration.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Hexan-1-ol
EC Number:
203-852-3
EC Name:
Hexan-1-ol
Cas Number:
111-27-3
IUPAC Name:
hexan-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: intratracheal
Vehicle:
unchanged (no vehicle)
Details on exposure:
Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and  then closing the nostrils during inspiration. 
Doses:
0.2 ml
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and  then closing the nostrils during inspiration. 

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: lethality by aspiration
Effect level:
0.2 other: ml per animal
Based on:
test mat.
Mortality:
Animals were induced to aspirate the test substance by placing 0.2 ml of the test substance into the mouth and  then closing the nostrils during inspiration.  10/10  animals died immediately.  The cause of death was  suspected to be respiratory or cardiac arrest, or both.
Clinical signs:
The lungs showed small areas of focal pulmonary hemorrhage and edema.

Applicant's summary and conclusion

Conclusions:
Acute Exposure/ Aspiration of 0.2 ml of hexyl alcohol by the rat caused respiratory arrest and instant death. The lungs showed small areas of focal pulmonary hemorrhage and edema.