Registration Dossier
Registration Dossier
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EC number: 276-769-3 | CAS number: 72705-22-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study but without GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Ammonium 4-acetoacetylamino-5-methoxy-2-methylbenzenesulphonate
- EC Number:
- 276-769-3
- EC Name:
- Ammonium 4-acetoacetylamino-5-methoxy-2-methylbenzenesulphonate
- Cas Number:
- 72705-22-7
- Molecular formula:
- C12H15NO6S.H3N
- IUPAC Name:
- ammonium 4-acetoacetylamino-5-methoxy-2-methylbenzenesulphonate
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -2.7
- Temp.:
- 23 °C
- pH:
- ca. 7
- Details on results:
- determ. no. stock solution [ml] n-octanol [ml] test substance conc. test substance conc log Pow
in n-octanol phase.[mg/l] in water phase [mg/l]
A 10 20 6,9 2835 -2,61
B 20 20 5,4 2770 -2,71
C 40 20 5,3 2797 -2,72
mean --- --- --- --- -2,7
Recovery rate: 98 - 101%
Applicant's summary and conclusion
- Conclusions:
- The Log Pow of tjhe substance is -2.7 at 23°C.
- Executive summary:
The partition coefficient (log Pow) of the test substance N-acetoacetyl cresidine sulphonic acid, ammonium salt was determined according to the OECD Guideline for the Testing of Chemicals 107and was found to be -2.7 at 23°C.
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