Registration Dossier
Registration Dossier
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EC number: 234-439-6 | CAS number: 12003-78-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only few data about test conditions, no data if GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines of the Department of Transportation (D.O.T.), Code of Federal Regulations, Title 49, Part 173
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium, compound with nickel (1:1)
- EC Number:
- 234-439-6
- EC Name:
- Aluminium, compound with nickel (1:1)
- Cas Number:
- 12003-78-0
- Molecular formula:
- Al.Ni
- IUPAC Name:
- aluminum - nickel (1:1)
- Test material form:
- solid: particulate/powder
- Details on test material:
- dark grey fine powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- weight: ca. 3 kg
acclimation: 7 days
Test system
- Vehicle:
- other: as liquid or as powder
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- Liquid: 0.1 ml
Powder: 100 mg - Duration of treatment / exposure:
- One time treatment
- Observation period (in vivo):
- 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Test item was instilled into the conjunctival sac of one eye. The opposite eye remained untreated and served as control.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: visual inspection
- Remarks:
- Fluorescein staining and oberservation of the cornea using an UV lamp.
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
No irritation was observed under the conditions of this test.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Test item is not irritating.
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