Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-439-6 | CAS number: 12003-78-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information is given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines of the Department of Transportation (D.O.T.), Code of Federal Regulations, Title 49, Part 173
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium, compound with nickel (1:1)
- EC Number:
- 234-439-6
- EC Name:
- Aluminium, compound with nickel (1:1)
- Cas Number:
- 12003-78-0
- Molecular formula:
- Al.Ni
- IUPAC Name:
- aluminum - nickel (1:1)
- Test material form:
- solid: particulate/powder
- Details on test material:
- dark grey fine powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - healthy albino rats
- weighing 100 - 150 gr
- animals were housed five per wire mesh suspended cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Based on the range finding results, five male and five female rats were gavaged in a similiar manner, see preliminary study.
- Doses:
- 31,600 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex
- Control animals:
- no
- Details on study design:
- Body weights were recorded at dosing and at 48 hours for the survivors.
Clinical signs were noted immediately after dosing and at 4, 24 and 48 hours.
Animals found dead or terminated at 48 hours were subjected to a macroscopic examination of the viscera. - Statistics:
- LD50 was calculated according to the method of Litchfield and Wilcoxon, Pharmacol. and Exp. Ther., 96:99, 1949
Results and discussion
- Preliminary study:
- Following a 7-day period, a series of range finding doses were given by gavage to rats fasted overnight.
Doses in the range finding:
No. Dead/No. Dosed
10,000 mg/kg bw 0/2
6,320 mg/kg bw 0/2
3,980 mg/kg bw 0/2
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 31 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Results of Main Study
No. Dead/No. Dosed
31,600 mg/kg bw 0/10 - Clinical signs:
- other: Animals at the highest dose appeared normal after dosing.
- Gross pathology:
- Macroscopic changes were not observed in the viscera.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The 48 hour LD50 is calculated at greater than 31,600 mg/kg in the rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
