Registration Dossier
Registration Dossier
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EC number: 221-916-9 | CAS number: 3279-27-4
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Evidence of the biodegradation potential for o-tert-amylphenol was concluded from the results of numerous biodegradation studies with both, the substance itself as well as with the read across substances o-tert-butylphenol and o-sec-amylphenol.
In most of the studies, either OECD 301 or OECD 302 studies, the criteria for inherent biodegradtion were fulfilled. Therefore o-tert-amylphenol is regarded as inherently biodegradable. Hence, the substance is not persistent (P).
Reliable measured and modeled BCF data for o-tert-amylphenol and its structural analogues o-tert-butylphenol and o-sec-butylphenol are available and included in the dossier. Chemical Evaluation and Research Institute Japan (2008) provide a measured BCF value of 78 for the common carp exposed to the read across substance o-tert-butylphenol. Consequently, this value will be taken for the aquatic bioaccumulation in aquatic organisms endpoint.
Reliable modeled BCF value for o-tert-amylphenol, using the measured log Kow of 4.0 was estimated to be 121 L/kg wt for earthworm. These data indicate that there is very low potential for bioaccumulation of o-tert-amylphenol in terrestrial organisms.
Aquatic toxicity tests indicate the substance does not meets the criteria to be regarded as toxic (T). Furthermore o-tert-amylphenol is not classified as carcinogenic, germ cell mutagenic, or toxic for reproduction or STOT.
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