Registration Dossier
Registration Dossier
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EC number: 221-916-9 | CAS number: 3279-27-4
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The long-term toxicity of o-tert-amylphenol was estimated using a QSAR model. The 30 day ChV was 0.262 mg/L and the calculated NOEC was 0.185 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.185 mg/L
Additional information
No reliable experimental long-term toxicity studies with fish are available for o-tert-amylphenol. However reliable (Klimisch 2) modeled data are available and included in the dossier.
Sasol (2016) provided reliable (Klimisch 2) data for o-tert-amylphenol using the QSAR model, Ecological Structure Activity Relationships (ECOSAR) Class Program to estimate long-term toxicity to fish. The ECOSAR model estimates aquatic toxicity based on the structural similarity to chemicals for which aquatic studies are available. In addition, the log Kow and molecular weight of o-tert-amylphenol are within the criteria (max log Kow = 7 for acute, 8 for chronic and max molecular weight = 1000) and domain of the model. The measured log Kow of 4.0 was used in the model. Model results indicate a 30 day chronic value (the geometric mean of the NOEC and LOEC) to be 0.262 mg/L using the baseline toxicity equation. As per REACH Guidance Ch 10, a NOEC can be calculated from the chronic value. Therefore, the calculated NOEC is 0.185 mg/L.
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