Registration Dossier
Registration Dossier
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EC number: 232-102-8 | CAS number: 7786-67-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Isopulegol
- EC Number:
- 201-940-6
- EC Name:
- Isopulegol
- Cas Number:
- 89-79-2
- IUPAC Name:
- 2-isopropenyl-5-methylcyclohexanol
- Reference substance name:
- 5-methyl-2-(1-methylvinyl)cyclohexan-1-ol
- EC Number:
- 232-102-8
- EC Name:
- 5-methyl-2-(1-methylvinyl)cyclohexan-1-ol
- Cas Number:
- 7786-67-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- 5-methyl-2-(prop-1-en-2-yl)cyclohexan-1-ol
- Details on test material:
- Name of test material: Isopulegol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 5 different doses: 0.313, 0.625, 1.25, 2.5 and 5 g/kg/bodyweight
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Observations were made at ½, 1, 2, 4, 24 h and thereafter, once daily for 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 030 mg/kg bw
- Mortality:
- Death occurred at 0.625 ml/kg in onen male, three animals per sex at 1.25 ml, 10/10 at 2.5 ml/kg and 5.0 ml/kg.
- Clinical signs:
- other: Toxic symptoms included salivation, respiratory congestion, and slight ataxia at 0.313 ml/kg within one-half hour. Ataxia was also noted at 1 h and slight ataxia was observed at two hours. Symptoms intensified, in all animals, as dosage levels increased.
Applicant's summary and conclusion
- Conclusions:
- The LD50 is 1030 mg/kg of body weight.
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