Allyl alcohol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Peer reviewed publication, suitable for assessment

Data source

Reference

Reference Type:

publication

Title:

The toxicity of allyl alcohol.

Author:

Dunlap, M.K., Kodama, J.K., Wellington J.S., Anderson, H.H., Hine, C.H.

Year:

1958

Bibliographic source:

AMA archives of industrial health. 18:303-311

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test substance was applied to the dorsal area of male albino rabbits (to both intact and scarified areas). These areas were covered with patches of gauze and rubber dam and held in place with adhesive tape. Treated areas were examined after 24 hours.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Allyl alcohol

EC Number:

203-470-7

EC Name:

Allyl alcohol

Cas Number:

107-18-6

Molecular formula:

C3H6O

IUPAC Name:

prop-2-en-1-ol

Details on test material:

Allyl alcohol was 98.5% pure and was provided by the Shell Chemical Company. (Impurities are diallyl ether and water).

Test animals

Species:

rabbit

Strain:

other: albino

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Housing: individually housed in cages
- Diet (e.g. ad libitum): standard pellets ad libitum
- Water (e.g. ad libitum): ad libitum

Test system

Type of coverage:

occlusive

Preparation of test site:

other: intact and scarified

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5ml of undiluted pure allyl alcohol was applied.

Duration of treatment / exposure:

24 hours

Observation period:

Up to 48 hours after test substance application

Number of animals:

3

Details on study design:

TEST SITE
- Area of exposure: back
- Type of wrap if used: Patches of gauze under rubber dam fastened with adhesive tape.

Results and discussion

In vivo

Results

Irritation parameter:

erythema score

Remarks:

slight

Basis:

animal #1

Time point:

24 h

Reversibility:

fully reversible within: 48h

Remarks on result:

probability of weak irritation

Irritant / corrosive response data:

One rabbit showed a slight erythema where allyl alcohol had been applied to the intact skin 24 hours previously. This had disappeared by the end of 48 hours and no other reactions were noted.

Any other information on results incl. tables

Irritation was not scored using a recognised method. Irritation was assessed using visual observation. Therefore the irritation/corrosion results table has not been filled in as no irritation parameter was used.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

In this study allyl alcohol was slightly irritating to the skin.

Executive summary:

In a primary dermal irritation study, 3 male New Zealand white rabbits were dermally exposed to 0.5 ml of undiluted allyl alcohol without vehicle for 24 hours.  Animals then were observed for 48 hours.  Irritation was assessed via visual inspection.

 

In this study, allyl alcohol was slightly irritating to the skin of male rabbits.