Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
8 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
15 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available
Acute/short term exposure
Hazard assessment conclusion:
no-threshold effect and/or no dose-response information available

Workers - Hazard for the eyes

Additional information - workers

TiOCl2 occurs as intermediate compound during the hydrolysis process of parent compound titanium tetrachloride, and only can get stabilised in aqueous medium in coexistence with hydrochloric acid. In the physiologically relevant pH range TiOCl2 will hydrolyse rapidly and completely to final hydrolysis products titanium dioxide and hydrochloric acid.

The toxicity of TiOCl2 therefore is mainly driven by the caustic action of HCl that is formed upon hydrolysis. Due to this hydrolytical instability and the chemical nature of the hydrolysis products (gaseous hydrochloric acid and TiO2 particles) systemic exposure is negligible.

As TiOCl2 (1) only can occur in aqueous medium in coexistence with hydrochloric acid, and (2) during the process of hydrolysis of titanium oxychloride HCl is getting formed in bimolar quantities, it is proposed to assess titanium oxychloride containing aqueous media in general as skin corrosive. Dermal load therefore has to be considered as unlikely, but assuming that it occurs the user will have reacted on the burning/itching skin sensation and will automatically start using gloves. The corresponding risk management measures to be implemented are supposed to be adequate to cover a potential risk of local dermal toxicity effects. Diluted, irritating hydrogen chloride will have no effect on systemic toxicity.

The assessment of inhalation hazards of titanium oxychloride is based on the fact that its stabiliser hydrochloric acid is a noted respiratory irritant if c(HCl) > 10% (acc. to harmonised classification under CLP). Concerning possible short-term local effects, the SCOEL recommends a STEL (15 min) of 10 ppm (15 mg/m3). This value will be used as DNEL for acute inhalation exposure. Concerning possible long-term local effects, the SCOEL recommends a TWA 8 hour of 5 ppm (8 mg/m3). This value will be used as DNEL for long term inhalation exposure.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
exposure based waiving
Acute/short term exposure
Hazard assessment conclusion:
exposure based waiving
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

Due to the hydrolytical instability exposure of the general public to TiOCl2 is not possible. The general public will only be exposed to the hydrolysis products which are hydrochloric acid and TiO2 particles. For these substances own registration dossiers exist and corresponding DNELs can be found there.