Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-712-3 | CAS number: 69-72-7
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comprehensive peer-reviewed safety assessment of MeS providing a detailed review of experimental data on all toxicological endpoints.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Fragrance material review on methyl salicylate
- Author:
- Lapczynski A, Jones L, McGinty D et al
- Year:
- 2 007
- Bibliographic source:
- Food Chem Toxicol 45:S428-S452
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Peer-reviewed safety assessment
Test material
- Reference substance name:
- Methyl salicylate
- EC Number:
- 204-317-7
- EC Name:
- Methyl salicylate
- Cas Number:
- 119-36-8
- Molecular formula:
- C8H8O3
- IUPAC Name:
- Methyl 2-hydroxybenzoate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- This comprehensive, peer-reviewed, safety assessment of MeS summarises data covering all toxicological endpoints, from both published sources and unpublished reports not otherwise accessible. Data published in this report are considered acceptable for use as supporting information under a number of specific toxicological endpoints.
- Executive summary:
This review (Lapczynski et al, 2007) summarises the data on methyl salicylate which is included in the full review of salicylates used as fragrance ingredients by the RIFM Expert Panel.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
