Registration Dossier
Registration Dossier
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EC number: 202-429-0 | CAS number: 95-53-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (few informations, investigated for dose finding only)
Data source
Reference
- Reference Type:
- publication
- Title:
- Vergleichende Kanzerogenese Versuche mit 2,4-Toluylendiamin, 2,4/2,6-Toluylendianin 80/20, m-Phenylendiamin, o-Toluidin, p-Toluidin, 4,4'-Diaminodiphenylnethan, Benzidin, bei subkutaner Applikation an Ratten
- Author:
- Bayer AG, Steinhoff D, Dycka
- Year:
- 1 981
- Bibliographic source:
- Unpublished report No 10682, July 06, 1981
Materials and methods
- Principles of method if other than guideline:
- dose finding for a cancerogenicity study
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- o-toluidine
- EC Number:
- 202-429-0
- EC Name:
- o-toluidine
- Cas Number:
- 95-53-4
- Molecular formula:
- C7H9N
- IUPAC Name:
- 2-methylaniline
- Details on test material:
- - Name of test material (as cited in study report): o-toludine
- Analytical purity: > 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- peanut oil
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 115 mg/kg bw
- 95% CL:
- 984 - 1 295
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
