Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-931-2 | CAS number: 112-05-0
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: 3a: Significant methodological deficiences
Data source
Reference
- Title:
- No information
- Author:
- Boelsma, E.; Tanojo, H.; Bodde H.E. and Ponec, M. (1997): An in vivo-in vitro study of the use of a human skin equivalent for irritancy screening of fatty acids. Toxicology in Vitro, 11, 365-376 [T 01705]
Materials and methods
Test material
- Reference substance name:
- Nonanoic acid
- EC Number:
- 203-931-2
- EC Name:
- Nonanoic acid
- Cas Number:
- 112-05-0
- Molecular formula:
- C9H18O2
- IUPAC Name:
- nonanoic acid
- Details on test material:
- IUCLID4 Test substance: no data
TS-Freetext:
n-Nonanoic acid [CAS No. 112-05-0], not further specified, from Sigma Chemicals
Constituent 1
Test animals
- Species:
- human
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- other: polyethylene glycol
- Frequency of treatment:
- 1x
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.16 M
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Type: other: in vivo and in vitro
Results and discussion
Any other information on results incl. tables
RS-Freetext:
At the concentration used and test conditions applied the saturated fatty acid exhibited no significant or only slight increases in the indicated parameters. Higher effects were observed with the unsaturated fatty acids.
-----------
Applicant's summary and conclusion
- Conclusions:
- CL-Freetext:
The assay appears to be sensitive, but not yet validated, only one diluted solution was applied (about 2.5 % = 0.16 M).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
