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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other: QSAR toolbox
Title:
QSAR Study for 2580-78-1
Year:
2011
Bibliographic source:
OECD QSAR toolbox version 2.2, 2011; National Institute of Technology and Evaluation Japan; Research Institute for Animal Science in Biochemistry & Toxicology; 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Reference substance name:
2-(3-(4-amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)aminobenzenesulphonyl)vinyl) disodium sulphate
EC Number:
219-949-9
EC Name:
2-(3-(4-amino-9,10-dihydro-3-sulpho-9,10-dioxoanthracen-4-yl)aminobenzenesulphonyl)vinyl) disodium sulphate
Cas Number:
2580-78-1
IUPAC Name:
disodium 1-amino-9,10-dioxo-4-[(3-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)amino]-9,10-dihydroanthracene-2-sulfonate
Details on test material:
Purity- 77.1

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Duration of treatment / exposure:
Administration period- 28 days
Doses / concentrations
Remarks:
Doses / Concentrations:
40 - 1000 mg/kg
Basis:
no data

Results and discussion

Results of examinations

Details on results:
Recovery period (day):14

Effect levels

Dose descriptor:
NOEL
Effect level:
1 000 other: mg/kg/day
Based on:
test mat.
Sex:
male
Basis for effect level:
other: Death, Increased body weight, Decreased body weigh, Increased food consumption, Decreased food consumption, Hyperthermia,Hypothermia

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Repeated dose toxicity value of the substance on rat(male) is NOEL:1000 mg/kg/day.