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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Danish (Q)SAR Database
Title:
Danish (Q)SAR Study for 2494-88-4
Year:
2012
Bibliographic source:
Commercial

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Ames mutagenicity. Multicase model.
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(3-aminophenyl)sulphonyl] hydrogensulphate
EC Number:
219-668-1
EC Name:
2-[(3-aminophenyl)sulphonyl] hydrogensulphate
Cas Number:
2494-88-4
Molecular formula:
C8H11NO6S2
IUPAC Name:
[2-(3-aminobenzenesulfonyl)ethoxy]sulfonic acid

Results and discussion

Test results
Species / strain:
other: Salmonella
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
no cytotoxicity
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
AMES test of the substance to Salmonella is negative.