3,5-diiodosalicylic acid

Endpoint summary

Description of key information

The substance 3,5-diiodosalicylic acid was found to be non toxic by any of the following route.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Species:

mouse

Strain:

other: ICR;B6C3F1;ddY;no data;Swiss

Sex:

not specified

Route of administration:

other: oral: gavage;oral: unspecified

Vehicle:

not specified

Control animals:

not specified

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 410.333 mg/kg bw

Based on:

test mat.

The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain  logical expression:Result: In Domain

(("a" and ("b" and ( not "c") )  )  and ("d" and "e" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Phenols (Acute toxicity) by US-EPA New Chemical Categories

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O AND Group 17 - Halogens F,Cl,Br,I,At AND Group 17 - Halogens I by Chemical elements

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N OR Group 17 - Halogens Br OR Group 17 - Halogens Cl by Chemical elements

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.33

Domain logical expression index: "e"

Parametric boundary:The target chemical should have a value of log Kow which is <= 5.03

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The Acute oral toxicity (LD50) value of 3,5-diiodosalicylic acid on Rat on the basis of mortality effect was estimated to be 2410.33 mg/kg bw. This value indicates that the substance 3,5-diiodosalicylic acid is not toxic to Rat by oral route.

Executive summary:

The Acute oral toxicity (LD50) value of 3,5-diiodosalicylic acid on Rat on the basis of mortality effect was estimated to be 2410.33 mg/kg bw. This value indicates that the substance 3,5-diiodosalicylic acid is not toxic to Rat by oral route.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 410.33 mg/kg bw

Quality of whole database:

The data is predicted for QSAR toolbox 3.1. Based upon this available data it is expected that the test chemical 3,5-diiodosalicylic acid does not exhibit acute oral toxicity to rat within the mentioned dose level.

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Additional information

Acute Toxicity -Oral:

The data has been obtained from the prediction done in QSAR 3.1 & other study from the reliable sources.

The summary of the results are presented below:

 

Sr. No	Endpoint	Species	Route	Effect Level	Sources
1	LD50	Rat	oral: gavage	2410.33 mg/kg bw	QSAR Prediction
2	LD50	Rattus norvegicus	oral: unspecified	2894.22mg/kg bw	QSAR Prediction
3	LD50	Rat	oral: gavage	3581.4934 mg/kg bw	QSAR Prediction
4	LDLo	Rat	oral: unspecified	500 mg/kg	Chemical-Biological Coordination Center,
5	LD50	Mouse	oral: unspecified	450 mg/kg bw	Quarterly Journal of Pharmacy & Pharmacology

  

By viewing the above values the endpoint value was found to be median Lethal Dose (LD50) ranges from 3581.4934 to 500 mg/kg bw.

According to new CLP regulation, these values indicates that the substance3,5-diiodosalicylic acid is non toxic via oral route

 

Justification for selection of acute toxicity – oral endpoint
The predicted acute oral lethal dose (LD50) of 3,5-diiodosalicylic acid in rat was 2410.33 mg/kg of body weight. Acute toxicity of 3,5-diiodosalicylic acid to rat by oral gavage route indicates that 3,5-diiodosalicylic acid does not exhibits acute toxicity by the oral route within the dose level mentioned in the study.

Justification for classification or non-classification

Based upon the study results and available information, the substance3,5-diiodosalicylic acid is not expected to show acute toxicity effect by the oral route.