3,5-diiodosalicylic acid

Endpoint summary

Additional information

Short-term toxicity to fish :

No. of predictions done for short term fish toxicity endpoints having Klimish rating 2

The summary of the results are presented below:

 

Sr. No	Endpoint name	Value	Effect	Species	Source
1	LC50	6.449672699 mg/l	Mortality	Oryzias latipes	SSS QSAR
2	LC50	5.768873215 mg/l	Mortality	Pimephales promelas	SSS QSAR
3	LC50	3.296432972 mg/L	Mortality	Cyprinodon variegatus	SSS QSAR
4	LC50	7.42 mg/L	Mortality	Fish	ECOSAR
5	LC50	10 mg/L	Mortality	Ptychocheilus oregonensis : Northern Squawfish	ECOTOX

 

After comparing the short term toxicity values from predictions done in QSAR rtoolbox 3.1 & estimated data from ECOSAR & ECOTOX. it was estimated values varies from 3.296432972 to 10 mg/l . But the BCF value of 3,5-diiodosalicylic acid reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification. It is concluded that 3,5-diiodosalicylic acid does not exhibit short term toxicity to fish.

 

Short-term toxicity to aquatic invertebrates :

No. of predictions done for short term Aquatic invertebrate endpoints having Klimish rating 2

The summary of the results are presented below:

 

Sr. No	Endpoint name	Value	Effect	Species	Source
1	EC50	7.907 mg/L	Mobility	Daphnia magna	SSS QSAR
2	LC50	7.045 mg/L	Mortality	Daphnia magna	ECOSAR Version 1.10
3	EC50	1.889201522 mg/L	Intoxication	Daphnia magna	SSS QSAR

 

After comparing the short term toxicity values from predictions & estimated calculation. It was found to be varies from 1.889201522 to 7.097 mg/l. But the BCF value of 3,5-diiodosalicylic acid reported was not >= 500 as well as the substance was found to be rapidly degradable Thus considering only the value from CLP Criteria for aquatic classification of the substance , it is concluded that 3,5-diiodosalicylic acid does not exhibit short term toxicity to Aquatic invertebrate (Daphnia magna).

 

Toxicity to aquatic algae and cyanobacteria:-

No. of predictions done for short termtoxicity to algae and cynobacteriaendpoints having Klimish rating 2.

The summary of the results are presented below:

 

Sr. No	Endpoint name	Value	Effect	Species	Source
1	EC50	22.351 mg/l	Growth rate	Selenastrum capricornutum (new name: Pseudokirchnerella subca	SSS QSAR
2	EC50	25.221 mg/L	-- --- ---	Green Algae	ECOSAR Version 1.10
3	EC50	3.954859257 mg/L	Growth rate	Selenastrum capricornutum (new name: Pseudokirchne	SSS QSAR
4	EC50	7.045009136 mg/L	Growth rate	Pseudokirchneriella subcapitata	SSS QSAR

 

After comparing the Toxicity to algae and cynobacteria values from QSAR 3.1 predictions & estimated calculations. it was found to be varies from 3.954 to 25.221 mg/L The BCF value of 3, 5-diiodosalicylic acid reported was not >= 500 as well as the substance were found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.