2-[(4-chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide

Nanomaterial dustiness

Administrative data

Endpoint:

nanomaterial dustiness

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24 Jul 2020 - 16 Sep 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Remarks:

According to DIN EN 17199-3

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: DIN EN 17199-3

Version / remarks:

DIN EN 17199-3:2019-12 “Workplace exposure - Measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method

Deviations:

yes

Remarks:

1 measurement performed

GLP compliance:

no

Type of method:

continuous drop

Sampling:

The test material was used without further treatment (e.g. drying). The relative humidity of the test atmosphere was 51%. 59.4 g (259.4 cm³) test material was used for the measurement, at a dosing rate of 5.94 g/min. 1 measurement was performed for background and sample, with a measurement duration of 3 and 10 minutes, respecitvely.

Test material

Test material information

Constituent 1

Reference substance name:

2-[(4-chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide

EC Number:

236-852-7

EC Name:

2-[(4-chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutyramide

Cas Number:

13515-40-7

Molecular formula:

C17H15ClN4O5

IUPAC Name:

2-[(4-chloro-2-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide

Test material form:

solid: nanoform, no surface treatment

Results and discussion

Dustiness index

Dustiness index 1

Key result

Mean:

37 366 other: particles/mg

Remarks on result:

other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)

Dustiness index 2

Mean:

4 188 other: particles/cm³

Remarks on result:

other: number of airborne nanoparticles per cm³, size range 10-100 nm

Any other information on results incl. tables

The cleaned, almost particle-free air had a total particle count of 6 particles/cm³ in the range of 10 nm – 417 nm, whereby the nanoscale fraction (10 - 100 nm) contained 4 particles/cm³.

 

Summary SMPS result:

Range [nm]	Mean [nm]	Concentration [ particles /cm³]	I(CD) [particles/mg]	E(CD) [1/mg·s]
10 -100	73.1	4187.8	37365.8	62.3
100 - 417	186.7	16277.7	145238.4	242.1
10 - 417	163.5	20465.4	182604.2	304.3

 

Summary OPS result:

Range [µm]	Mean [µm]	Concentration [ particles /cm³]	I(CD) [particles/mg]	E(CD) [1/mg·s]
0.3 - 10	5.6	95.7	854.2	1.4

 

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199-3:2019-12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by clean, almost particle-free air.

The SMPS counted 4188 particles in the nanoscale (10 - 100 nm) per cm³, corresponding to a dustiness index of 37366 particles in the nanoscale (10 - 100 nm) per mg. The particle number in the whole SMPS size range (10-417 nm) was 16278 per cm³, corresponding to a dustiness index of 145238 particles/mg (size 10 - 417 nm).

The mean size of the nanoparticles was 73.1 nm, the mean size of particles in the range 10 - 417 nm was 186.7.

The OPS (0.3 - 10 µm) counted 95.7 particles per cm³ corresponding to a dustiness index of 854 particles per mg. The mean size of the particles was 5.6 µm.