Registration Dossier
Registration Dossier
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EC number: 275-639-3 | CAS number: 71566-54-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited data given. Deficiencies: - no detailed information on animals, husbandry, performance of the test, test substance, cageside/clinical observations - only 1 animal per dose group
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (no detailed information on animals, husbandry, performance of the test, test substance, cageside/clinical observations; only 1 animal per dose group)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diisopropyl 3,3'-[(2,5-dichloro-1,4-phenylene)bis[iminocarbonyl(2-hydroxy-3,1-naphthylene)azo]]bis[4-methylbenzoate]
- EC Number:
- 275-639-3
- EC Name:
- Diisopropyl 3,3'-[(2,5-dichloro-1,4-phenylene)bis[iminocarbonyl(2-hydroxy-3,1-naphthylene)azo]]bis[4-methylbenzoate]
- Cas Number:
- 71566-54-6
- Molecular formula:
- C50 H42 Cl2 N6 O8
- IUPAC Name:
- diisopropyl 3,3'-[(2,5-dichloro-1,4-phenylene)bis[iminocarbonyl(2-hydroxy-3,1-naphthylene)azo]]bis[4-methylbenzoate]
- Test material form:
- not specified
- Details on test material:
- - Batch No.: 2511/72
No further details.
Constituent 1
- Specific details on test material used for the study:
- - Batch No.: 2511/72
- Physical state: Red powder
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.08, 2.88, 2,70 kg
No further details.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
The skin at the site of application was abraded. - Duration of exposure:
- No data.
- Doses:
- 300, 1000, 3000 mg/kg
- No. of animals per sex per dose:
- 1
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: day 1, 7, 14
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: neither mortality nor clinical signs indicative of toxicity were observed during the 14-day observation period.
- Mortality:
- No animal died.
- Clinical signs:
- other: No pharmacotoxic symptoms were observed in any of the rabbits following dermal exposure to the test material.
- Gross pathology:
- Necropsy examination of all rabbits at the end of the 14-day observation period did not reveal any gross pathologic alterations.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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