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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Meets the then current EPA guidelines, therefore comparable to OECD 413.
- GLP compliance:
- yes
- Limit test:
- no
Test animals
- Species:
- other: Rat, Fischer-344 albino
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: Air.
- Details on inhalation exposure:
- Method of exposure:
Whole body inhalation
Mass median aerodynamic diameter:
The micronised test material was particle sized and found to
have an equivalent aerodynamic diameter of 4.7 microns with
a GSD of 2.24. - Duration of treatment / exposure:
- Test duration: 90 days
- Frequency of treatment:
- Duration of exposure per day: 6 hours
Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 10 animals at 22 mg/l
Male: 10 animals at 80 mg/l
Male: 10 animals at 251 mg/l
Female: 10 animals at 22 mg/l
Female: 10 animals at 80 mg/l
Female: 10 animals at 251 mg/l
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
No animals died over the course of the study, and no
exposure-related pharmacotoxic signs were noted. Both males
and femals exposed to 251 mg/m3 exhibited depressed
bodyweights. At 22 mg/m3 bodyweights were similar to
controls. Food consumption was very slightly depressed but
only at the 251 mg/m3 exposure level.
Laboratory findings:
Serum vanadium levels were elevated in a dose-related
manner, but the increases were not proportional to dose. No
ophthalmological abnormalities were noted. Elevated
erythrocyte counts and depressed MVC, MCH and MCHC levels
were noted in exposed animals. Platelet counts were also
elevated in both males and females exposed to the high
level. Some serum biochemical differences were noted, i.e.,
elevated alanine aminotransferase and urea nitrogen levels,
but the significance of these observations could not be
determined from the data available.
Effects in organs:
As expected from an inhalation dust exposure, lung weights
were elevated and mediastinal lymph nodes were enlarged.
Alveolar bronchiolisation was noted at the highest exposure
level, while type II pneumocyte hyperplasia was noted at the
lowest exposure level.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 80 mg/L air
- Basis for effect level:
- other: exposure duration: 6 hours/day
- Dose descriptor:
- NOEC
- Effect level:
- < 22 mg/L air
- Basis for effect level:
- other: exposure duration: 6 hours/day
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
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