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EC number: 406-260-5
CAS number: 58834-75-6
BTN; VPO CATALYST
No further details.
Computer-assisted sperm analysis was used to evaluate the spermicidal
activity of eight metallocene dihalides (vanadocene dichloride [VDC],
titanocene dichloride [TDC], zirconocene dichloride [ZDC], molybdocene
dichloride [MDC], hafnocene dichloride [HDC], vanadocene dibromide
[VDB], bis[methylcyclopentadienyl] vanadium dichloride [VMDC] and
vanadocene diiodide [VDI]); five vanadocene di-pseudohalides (vanadocene
diazide [VDA], vanadocene dicyanide [VDCN], vanadocene dioxycyanate
[VDOCN], vanadocene dithiocyanate [VDSCN] and vanadocene diselenocyanate
[VDSeCN]); and three disubstituted derivatives (vanadocene ditriflate
[VDT], vanadocene monochlorooxycyanate [VDCO] and vanadocene monochloro
acetonitrilo tetrachloroferrate [VDFe]). The metallocene complexes
containing titanium, zirconium, molybdenum, and hafnodium were inactive,
however all 12 vanadocene complexes elicited potent spermicidal activity
at nanomolar or micromolar concentrations with an order of efficacy
VDSeCN > VDSCN > VDB > VMDC > VDCN > VDA > VDC > VDOCN > VDI > VDT >
VDFe > VDCO. This activity was achieved without disruption of the
acrosomal membrane, as determined by high-resolution low-voltage
scanning electron microscopy. The sperm-immobilising activity of the
vanadocene complexes was rapid and irreversible, since the treated sperm
underwent apoptosis as determined by the flow cytometric annexin V
binding assay, DNA nick end-labeling, and confocal laser scanning
microscopy. The authors conclude that metallocene complexes containing
vanadium (IV), especially VDSeCN, may be useful as contraceptive agents.
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