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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1

In vivo test system

Study design: in vivo (non-LLNA)

No. of animals per dose:
Number of animals in test group: 4
Number of animals in negative control group: 4

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
5% (w/w)
10% (w/w)
25% (w/w)

Results and discussion

In vivo (LLNA)

Results
Parameter:
SI
Remarks on result:
other: 5% (w/w) 1.38 10% (w/w) 1.53 25% (w/w) 1.03

Any other information on results incl. tables

Concentration       Stimulation Index       Result

5% (w/w)       1.38       Negative    

10% (w/w)       1.53      Negative

25% (w/w)       1.03       Negative

Applicant's summary and conclusion

Interpretation of results:
other: not classified