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EC number: 695-977-9 | CAS number: 1309955-79-0
Mortality data on each occasion
No. of deaths
0 = animal survived; 1 animal died
The study was performed to assess the acute toxicity of the test material following a single oral administration to the HC/CFY (remote Sprague-Dawley) strain rat. The study was performed equivalent to OECD 425. A group of 11 fasted males and 12 fasted female was given a single, oral dose of the test material at dose levels between 800 and 5000 mg/kg bodyweight. The animals were observed for 7 days after the day of dosing and were then killed for gross pathological examination. Deaths were observed at levels 1260 mg/kg bw and higher. Clinical signs of toxicity noted were pilo-erection, hunched posture, abnormal gait, lethargy, pallor of the extremities, ptosis, diarrhoea, increased salivation, and decreased respiratory rate. Recovery was apparently complete by day 5 -8 (day 1 is day of dosing). All surviving animals showed expected gains in bodyweight over the study period. No abnormalities were noted in survivors at necropsy. Non-survivors generally showed haemorrhage or congestion of the lungs, and pallor of the liver, kidneys and spleen. The acute median lethal dose (LD50) of the test material (with 95% confidence limits) was found to be 1500 (1100 -2000) mg/kg bw in males, and 1200 (900 -1600) mg/kg bw in females. The test compound was therefore classified in Category IV according to OECD-GHS.
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