Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 695-953-8 | CAS number: 204918-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- prop-2-en-1-yl 2-(2-chloro-5-isocyanatobenzoyloxy)-2-methylpropanoate
- EC Number:
- 695-953-8
- Cas Number:
- 204918-22-9
- Molecular formula:
- C15H14ClNO5
- IUPAC Name:
- prop-2-en-1-yl 2-(2-chloro-5-isocyanatobenzoyloxy)-2-methylpropanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Scientifique des Dombes, F-01400 Chatillon sur Chalaronne / France
- Age at study initiation: Male 17 weeks. Females 14 weeks.
- Weight at study initiation: 2.6 - 3.1 kg
- Housing: Individual
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 3°C
- Humidity: 30 - 70 %
- Air changes: 10 - 15 per hour
- Photoperiod: 12 hours light/12 hours dark
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5ml (per animal)
- Concentration: undiluted as supplied
- pH: 6.0 - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3 (1 male, 2 females)
- Details on study design:
- TEST SITE
Four days before treatment, the left flank was clipped with an electric clipper, exposing an area of approximately 10 cm x 10 cm. The skin of the animals was examined approximately 24 hours before treatment, and regrown fur of all animals was clipped again.
On the day of treatment, 0.5 ml of test item were put on a surgical gauze patch (ca. 2.5 cm x 2.5 cm). This gauze patch was applied to the intact skin of the clipped area. The patch was covered with a semi-occlusive dressing. The dressing was wrapped around the abdomen and anchored with tape.
REMOVAL OF TEST SUBSTANCE
The duration of treatment was 4 hours. Then the dressing was removed and the skin was flushed with lukewarm tap water to clean the application site so that any reactions (erythema) were clearly visible at that time.
OBSERVATIONS:
Viability/Mortality: Daily from delivery of animals to the termination of the test.
Clinical Signs: Daily from delivery of animals to the termination of the test.
Body weights: At start of acclimatization, on the day of application and at termination of observation.
SCORING SYSTEM:
The skin reaction was assessed according to the numerical scoring system listed in the EEC Commission Directive 92/69/EEC at approximately 1, 24, 48 and 72 hours, as well as 7, 10 and 14 days after the removal of the dressing, gauze patch and test item.
TERMINAL SACRIFICE:
All animals were sacrificed at end of observation period.
No necropsy was performed.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 to 72 hours
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 to 72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Application of the test item to healthy intact skin did elicit a dry and inelastic skin at the 1 hour examination through 10 days after treatment in all animals. A very slight erythema was noted in only one animal at the 24 hour examination and persisted through 7 days.
- Other effects:
- Viability/Mortality: No clinical signs of systemic toxicity were observed in the animals during the test and observation period.
No mortality occurred.
Coloration: A light brown staining produced by the test article was observed on the test site during the whole observation period
and did not influence the skin reading.
Corrosion: No irreversible alterations of the treated skin were observed nor were corrosive effects noted on the treated skin of
any animal.
Body weights: The body weight of the animals was considered to be within the normal range of variability.
Any other information on results incl. tables
Individual Skin Irritation Scores
Animal Number |
Sex |
Evaluation Interval |
Corneal Opacity |
Iris |
|
64 65 66 |
M F F |
1 hour |
0 0 0 |
0 0 0 |
|
64 65 66 |
M F F |
24 hours |
1 0 0 |
0 0 0 |
|
64 65 66 |
M F F |
48 hours |
1 0 0 |
0 0 0 |
|
64 65 66 |
M F F |
72 hours |
1 0 0 |
0 0 0 |
|
64 65 66 |
M F F |
7 days |
1 0 0 |
0 0 0 |
|
64 65 66 |
M F F |
10 days |
0 0 0 |
0 0 0 |
|
64 65 66 |
M F F |
14 days |
0 0 0 |
0 0 0 |
|
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based upon the criteria stated in EEC Commission Directive 93/21/EEC, classification of CA 2814 B (Intermediate of CGA 276854) is not required.
- Executive summary:
The primary skin irritation potential of CA 2814 B (Intermediate of 276854) was investigated by topical application of 0.5 ml to 6 cm2intact left flank of each of three young adult New Zealand White rabbits. The duration of treatment of treatment was for 4 hours. The scoring of skin reactions was performed 1, 24, 48 and 72 hours as well as 7, 10 and 14 days after removal of the dressing. The scores of each animal at the 24, 48 and 72 hour reading times were used in calculating the respective mean values for each type of lesion.
Application of the test item to healthy intact skin did elicit a dry and inelastic skin at the 1 hour examination through 10 days after treatment in all animals. A very slight erythema was noted in only one animal at the 24 hour examination and persisted through 7 days.
The mean values from 24 to 72 hours (criteria for evaluation according the EEC Commission Directive 93/21/EEC) were 0.33 for erythema and 0 for oedema.
All skin reactions were clear within 14 days after treatment.
A light brown staining produced by the test article was observed on the test site during the whole observation period and did not influence the skin reading.
No corrosive effects were noted on the treated skin of any animal at any measuring interval.
Based upon the criteria stated in EEC Commission Directive 93/21/EEC, classification of CA 2814 B (Intermediate of CGA 276854) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.