Registration Dossier
Registration Dossier
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EC number: 700-713-3 | CAS number: 83161-22-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- yes
- Principles of method if other than guideline:
- Standard protocol n°CEPC.B.ETU.PRO.EPI.04
Study of cytotoxicity on reconstituted epiderm by quantification of different endpoints (MTT, LDH, IL1a and IL8) - GLP compliance:
- not specified
Test material
- Reference substance name:
- (2S,3R,4R,5R,6R)-2-methyl-6-(pentyloxy)oxane-3,4,5-triol
- EC Number:
- 700-713-3
- Cas Number:
- 83161-22-2
- Molecular formula:
- C11H22O5
- IUPAC Name:
- (2S,3R,4R,5R,6R)-2-methyl-6-(pentyloxy)oxane-3,4,5-triol
- Details on test material:
- For technical reason (solubility), APRC5 was diluted at 30% in a water/glycerol (1/5) mixture
This mixture corresponds to the industrial form.
Constituent 1
Test animals
- Details on test animals or test system and environmental conditions:
- test in vitro on reconstituted epiderm
Test system
- Type of coverage:
- other: in vitro test
- Vehicle:
- other: water/glycerol mixture
- Controls:
- yes
- Amount / concentration applied:
- APRC5 30%
- Duration of treatment / exposure:
- 72h
- Observation period:
- 72h
- Details on study design:
- test item : APRC5 30%
positive control item : Triton 4%
Results and discussion
In vivo
Results
- Irritation parameter:
- other: in vitro pamameters (LDH, IL1a, IL8)
- Remarks on result:
- other: slighly irritant
- Irritant / corrosive response data:
Any other information on results incl. tables
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Applicant's summary and conclusion
- Conclusions:
- slightly irritating
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