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EC number: 941-718-2
CAS number: -
data is being read across from the source study that tested
Hydrocarbons, C8-C11, n-alkanes, isoalkanes, <2% aromatics based on
analogue read across.
Primary skin irritation/corrosion
study with Hydrocarbons, C8-C11, n-alkanes, isoalkanes, <2% aromatics in
the rabbit (semi-occlusive application).
The study was carried out based on the
guidelines described in:
OECD No.404 (2002); "Acute Toxicity -
EC, No 440/2008; B4: "Acute Toxicity:
US EPA, OPPTS 870.2500 (1998), Acute
JMAFF Guidelines (2000), including the
most recent revisions.
Initially, one rabbit was exposed to
three samples of 0.5 mL of Hydrocarbons, C8-C11, n-alkanes, isoalkanes,
<2% aromatics applied to separate skin-sites on intact, clipped skin
using a semi-occlusive dressing. The exposure periods were 3 minutes, 1
hour and 4 hours, respectively. Skin reactions were assessed at least
once daily for 4 days after treatment and 7 and 14 days after exposure.
Based on the absence of severe skin reactions, two further animals
exposed for 4 hours to Hydrocarbons, C8-C11, n-alkanes, isoalkanes, <2%
aromatics at a later stage.
Exposure to Hydrocarbons, C8-C11,
n-alkanes, isoalkanes, <2% aromatics resulted in well-defined or
moderate to severe erythema and slight to moderate oedema in the treated
skin areas of the rabbits. Reduced flexibility, very superficial
fissuring, balding and/or scaliness were present from 7 days after
exposure onwards. Scaliness and/or bald skin persisted until termination
(14 Days after exposure).
Based on the 24-72 hours mean erythema
score of 2.3 in two animals and persisting skin reactions and according
Harmonized System of Classification and Labelling of Chemicals (GHS) of
the United Nations (2007) (including all amendments), Hydrocarbons,
C8-C11, n-alkanes, isoalkanes, <2% aromatics should be classified as :
skin irritant (Category 2).
- Regulation (EC) No 1272/2008 on
classification, labelling and packaging of substances and
mixtures(including all amendments), Hydrocarbons, C8-C11, n-alkanes,
isoalkanes, <2% aromatics should be classified as Irritant (Category 2)
and labeled as H315: Causes skin irritation.
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