Registration Dossier
Registration Dossier
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EC number: 419-740-4 | CAS number: 137658-79-8 CGL 1545
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test was conducted according to EU Method B.13/14 and compliant with GLP.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Phenol, 2-(4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-(3-((2- ethylhexyl)oxy)-2-hydroxypropoxy)-
- IUPAC Name:
- Phenol, 2-(4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-(3-((2- ethylhexyl)oxy)-2-hydroxypropoxy)-
- Reference substance name:
- 2-(4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-(3-((2-ethylhexyl)oxy)-2-hydroxypropoxy)phenol
- EC Number:
- 419-740-4
- EC Name:
- 2-(4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-(3-((2-ethylhexyl)oxy)-2-hydroxypropoxy)phenol
- Cas Number:
- 137658-79-8
- Molecular formula:
- C36H45N3O4
- IUPAC Name:
- 2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-{3-[(2-ethylhexyl)oxy]-2-hydroxypropoxy}phenol
Constituent 1
Constituent 2
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella thyphimurium Souches TA 1535, TA 1537, TA 98, TA 100 et Escherichia coli WP2 et WP2 uvrA
- Metabolic activation:
- with and without
- Metabolic activation system:
- S 9 mix
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 33.3 … 5000 µg/plate
Concentration range in the main test (without metabolic activation): 33.3 … 5000 µg/plate - Vehicle / solvent:
- Solvent: Acetone
Results and discussion
Test results
- Species / strain:
- other: as specified above
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity, but tested up to precipitating concentrations
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
The substnace showed no evidence of mutagenic activity when tested in this bacterial system with and without metabolic activation.
Cytotoxic concentration: Not cytotoxic up to 5000 µg/plate
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