Registration Dossier
Registration Dossier
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EC number: 231-445-0 | CAS number: 7554-65-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Animal experimental study, published in peer reviewed literature.
Data source
Reference
- Reference Type:
- publication
- Title:
- Kinetics of some pyrazole derivatives in the rat
- Author:
- Rydberg U.
- Year:
- 1 972
- Bibliographic source:
- J Pharm Pharmacol. 1972 Aug;24(8):651-2.
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Male Sprague-Dawley rats received the test substance via intraperitoneal injections. Blood samples were taken to determine the plasma half life.
- GLP compliance:
- no
Test material
- Reference substance name:
- 56010-88-9
- Cas Number:
- 56010-88-9
- IUPAC Name:
- 56010-88-9
- Details on test material:
- Name of test material (as cited in study article): 4-methylpyrazol hydrochloride
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Details on exposure:
- 4-methylpyrazole hydrochloride was dissolved in 2% saline
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.84 mmoL/kg
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY
- Tissues and body fluids sampled: blood
- Time and frequency of sampling: 50 µL blood samples were withdrawn from the tip of the tail and were diluted with sodium fluoride.
- Concentrations were determined with GLC.
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Test no.:
- #1
- Toxicokinetic parameters:
- half-life 1st: 544 ± 28 min (in blood)
- Test no.:
- #2
- Toxicokinetic parameters:
- other: mean maximum concentration: 0.84 mM (in blood)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
