(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Toxicity to soil macroorganisms except arthropods

Description of key information

The 14 day LC50 value to earthworms was determined to be >1000 mg/kg.

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil macroorganisms:

1 000 mg/kg soil dw

Additional information

An OECD 207 study (Earthworm, Acute Toxicity Test) was conducted on a structural analogue read-across substance (Gel All MD) to assess the acute toxicity of the substance to earthworms. The read-across substance (Gel All MD) is a close structural analogue of Gel All DX and comparison of the substances have shown them to be highly similar in phyisco-chemical properties and (eco)toxicological profile. It is therefore considered that the results from the read-across substance are valid for the assessment of Gel All DX.

6 replicate vessels, each containing 10 worms, were prepared at a concentration of 1000 mg/kg using an artificial soil. The exposure duration was 14 days.

A concurrent control (without exposure the test material) was also run. A positive control using Chloroacetamide was also run.

There were no significant mortalities or other adverse reactions to exposure in 60 earthworms exposed to a concentration of 1000 mg/kg for a period of 14 days. There were no significant differences between the worm weights of the control and 1000 mg/kg group on Days 0 and 14.

The 14 day LC50 value has been determined to be >1000 mg/kg.

The results from the positive control (Chloroacetamide) gave a 14 -day LC50 of 15 mg/kg, which was within the normal range for this compound.