Registration Dossier
Registration Dossier
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EC number: 941-650-3 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EL0 (5 h) = 2 mL/L for Pseudomonas putida (isododecane)
EL50 (48 h) > 1000 mg/L for Tetrahymena pyriformis (hydrocarbons, C11-C14, isoalkanes, cyclics, < 2% aromatics)
EL50 (3 h) > 100 mg/L for sludge respiration inhibition (hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, < 2% aromatics)
Key value for chemical safety assessment
Additional information
There are no data available on toxicity to microorganisms of Distillates (Fischer-Tropsch), 210-360 degree Celsius, hydrotreated, isoalkanes, cyclics, <0.1% aromatics.
Distillates (Fischer-Tropsch), 210-360 degree Celsius, hydrotreated, isoalkanes, cyclics, <0.1% aromatics consist of hydrocarbon solvents with predominant carbon numbers in the range of C11 to C19. The constituents of this solvent are single isomers as well as mixed solvents of which the primary constituents are branched chain (iso-), and cyclic aliphatic hydrocarbons. Aromatic constituents, if present, represent less than 0.1% of the total volume.
N-paraffins are only present in very low concentrations (<1%).
The carbon numbers in the range of C11 to C19 and initial distillation points (IBP) characterize the source substances. The distillation range of the source substances ranges from 220°C to 350 degree Celsius although some solvents may contain higher boiling material. The benzene and sulphur contents of source substances are low, benzene levels for example are typically <3 ppm.
The toxicology and environmental fate and effects data show that source substances have a similar order of (eco-)toxicological and environmental fate properties as the target substance. Therefore, read-across is performed based on an analogue approach (for details please refer to the analogue justification which is attached in section 13 of the technical dossier).
Testing isododecane in a non-guideline study according to GLP with Pseudomonas putida did not result in inhibition of the respiration rate at the highest loading rate of 2 mL/L over an exposure period of 5 hours (Sasol, 1994).
For hydrocarbons, C11-C14, isoalkanes, cyclics, < 2% aromatics, a QSAR model was calculated for the toxicity to the protozoan Tetrahymena pyriformis, which resulted in a 48-h EL50 value of > 1000 mg/L based on growth inhibition (Concawe, 2010).
Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, < 2% aromatics were tested according to OECD 209 (limit test) and GLP. The wastewater treatment plant activated sludge respiration inhibition 3-h EL50 value was > 100 mg/L (Pic, 1994).
These data are used as read-across data to Distillates (Fischer-Tropsch), 210-360 degree Celsius, hydrotreated, isoalkanes, cyclics, <0.1% aromatics. Based on these data, Distillates (Fischer-Tropsch), 210-360 degree Celsius, hydrotreated, isoalkanes, cyclics, <0.1% aromatics is not expected to exert toxic effects to wastewater treatment organisms at saturation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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