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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
publication: 1964
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Similar to guideline. Not cinducted under GLP. No information on doses administered; only calculated LD50 value.

Data source

Reference
Reference Type:
publication
Title:
Food flavouring and compounds of related structure. I Acute oral toxicity
Author:
Jenner, P.M. et al
Year:
1964
Bibliographic source:
Food Cosmetic |Toxicology, 2, 327-343.

Materials and methods

Principles of method if other than guideline:
Groups of 10 young adult Osborne-Mendel rats evenly divided by sex' were fasted for approximately 18 hr prior to treatment. Groups of guinea-pigs consisting of both males and females were fasted for the same period. Mice were treated on full stomachs. Animals had access to water at all times, and the food was replaced in cages as soon as animals received their respective doses. All doses were given by intubation. All animals were maintained under close observation for recording toxic signs and time of death. Such observation was continued until animals appeared normal and showed weight gain. The usual observation period was 2 weeks ; in a few cases, where no acute toxic; signs were seen, the animals were observed for only one week. LD50's were computed by the
method of Litchfield & Wilcoxon ( 1949).
GLP compliance:
no
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzaldehyde
EC Number:
202-860-4
EC Name:
Benzaldehyde
Cas Number:
100-52-7
Molecular formula:
C7H6O
IUPAC Name:
benzaldehyde

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female

Administration / exposure

Doses:
Not preciced.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 300 mg/kg bw
Mortality:
Animals died between 4 and 18 h after administration.
Clinical signs:
Depression and coma on higher doses.

Applicant's summary and conclusion

Conclusions:
Based on the results of this study, benzaldehyde needs to be classified acute oral toxicity Cat. 4 and R 22 according to Regulation (EU) 1272/2008 and EU Directive 67/548/EEC, respectively.