Registration Dossier
Registration Dossier
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EC number: 211-910-4 | CAS number: 709-55-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Concerning: Pre-Incubation Temperature for the Flask method; According to the Guideline: 30+- 1°C; Deviation to the Guideline: 30 +- 2°C; Reason for the Deviation: technical reason; Presumed Effect on the Study: none
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7860 (Water Solubility Generator Column Method)
Test material
- Reference substance name:
- Etilefrine
- EC Number:
- 211-910-4
- EC Name:
- Etilefrine
- Cas Number:
- 709-55-7
- Molecular formula:
- C10H15NO2
- IUPAC Name:
- 3-[2-(ethylamino)-1-hydroxyethyl]phenol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name: Effortil-Rohbase
Batch No: 310
Aggregate State at RT: solid
Colour: white
Purity: >98%
Analysis: meldting point
Certificate of Analysis: 19.07.2000
Storage: in orgiginal container, at room temperature, in the dark
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- ca. 63.7 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 9.8
- Remarks on result:
- other: Mean Value: 63.7mg/L; standard deviation: 0.713 mg/L
- Details on results:
- Results of the Preliminary Test
The water solubility of Effortil-Rohbase was estimated to be lower than 0.1 g/L.
Results of the Main Test
The saturation concentration of Effortil-Rohbase was estimated using photometric method. The linearity of the analytical method was proved in the concentration range from 10 to 100mg test item/L. The regression coefficient was determined to be 0.9999.
Corresponding to the analysis the water solubility of the test item was calculated to be 63.7 mg/L.
The water solubility of Effortil-Rohbase was determined to be 63.7 mg/L at 20 °C +- 1°C using flask method for the performance of the main test.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of Effortil-Rohbase was estimated to be lower than 0.1 g/L in a preliminary test.
The water solubility of Effortil-Rohbase was determined to be 63.7mg/L at 20 +- 1°C using the flask method for the performance of the main test.
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