Registration Dossier

Administrative data

First-aid measures

INHALATION:
Remove to fresh air. If any trouble breathing, get immediate medical attention. Administer artificial respiration if breathing has ceased. If irritation or symptoms occur or persist, consult a physician. Remove to fresh air. Administer artificial respiration if breathing has ceased. IMMEDIATELY consult a physician.

SKIN CONTACT:
In case of skin contact, while wearing protective gloves, carefully remove any contaminated clothing, including shoes, and wash skin thoroughly with soap and water. If irritation or symptoms occur or persist, consult a physician. In case of skin contact, IMMEDIATELY flush exposed skin thoroughly with plenty of water. While wearing protective gloves, remove any contaminated clothing, including shoes and continue to wash skin thoroughly with soap and water for at least 15 minutes. Get IMMEDIATE medical attention.

EYE CONTACT:
In case of eye contact, immediately rinse eyes thoroughly with plenty of water. If wearing contact lenses, remove only after initial rinse, and continue rinsing eyes for at least 15 minutes. If irritation occurs or persists, consult a physician.

INGESTION:
Do not induce vomiting unless under the direction of a qualified medical professional or Poison Control Center. IMMEDIATELY consult a physician. Do not attempt to give anything by mouth to a seizing, drowsy or unconscious person. If alert, rinse mouth and drink a glass of water.

FIRST AID RESPONDER PROTECTION: Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves with appropriate personal protective equipment. Induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. DO NOT use mouth-to-mouth method if victim ingested or inhaled the substance.

MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED
The toxicological properties of this material have not been fully characterized in humans and animals. Therefore, laboratory or process control systems and appropriate work practices should be in place to minimize the potential for inhalation exposure, skin contact, eye contact, or ingestion when working with this material. In animal studies, SCH 51048-FA caused slight to moderate eye irritation and central nervous system effects including sedation, poor coordination and labored breathing.

INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED
NOTE TO PHYSICIAN: This material is being evaluated for use as a pharmaceutical agent or in the manufacture of a pharmaceutical agent. No antidotes have been identified

Fire-fighting measures

SUITABLE EXTINGUISHING MEDIA:
Carbon dioxide (CO2), extinguishing powder or water spray.

SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE EXPLOSION HAZARDS:
Under normal conditions of use, this material does not present a significant fire or explosion hazard. However, like most organic compounds, this
material may present a dust deflagration hazard if sufficient quantities are suspended in air. This hazard may exist where sufficient quantities of finely divided material are (or may become) suspended in air during typical process operations. An assessment of each operation should be conducted and suitable deflagration prevention and protection techniques employed. The sensitivity of this material to ignition by electrostatic discharges has not been determined. In the absence of testing data, all conductive plant items and operations personnel handling this material should be suitably grounded.

Accidental release measures

PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES
PERSONAL PRECAUTIONS:
Avoid generation of dust during clean-up. Wear appropriate personal protective equipment as specified in Section 8. Keep personnel away from the clean-up area.

METHODS AND MATERIAL FOR CONTAINMENT AND CLEANING UP
SPILL RESPONSE / CLEANUP:
All spills should be handled according to site requirements and based on precautions cited in the MSDS. In the case of liquids, use proper absorbent
materials. For laboratories and small-scale operations, incidental spills within a hood or enclosure should be cleaned by using a HEPA filtered vacuum or
wet cleaning methods as appropriate. For large dry or liquid spills or those spills outside enclosure or hood, appropriate emergency response personnel
should be notified. In manufacturing and large-scale operations, HEPA vacuuming prior to wet mopping or cleaning is required.

Handling and storage

PRECAUTIONS FOR SAFE HANDLING
Keep containers adequately sealed during material transfer, transport, or when not in use. Wash face, hands, and any exposed skin after handling. Do
not eat, drink, or smoke when using this substance or mixture.
Appropriate handling of this material is dependent on many factors, including physical form, duration and frequency of process or task, and effectiveness
of engineering controls. Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness of all exposure control
measures. See Section 8 (Exposure Controls) for additional guidance.

CONDITIONS FOR SAFE STORAGE, INCLUDING ANY IMCOMPATIBILITIES
Store in dark container or away from light. Store in a cool, dry, well ventilated area.

Transport information

Land transport (ADR/RID)

UN number:
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Classification code:
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Inland waterway transport (ADN(R))

UN number:
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Marine transport (IMDG)

UN number:
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Proper shipping name and description:
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Chemical name:
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Class:
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Packaging group:
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EmS code:
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Air transport ICAO/IATA

UN number:
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Proper shipping name and description:
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Chemical name:
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Class:
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Labels:
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Exposure controls / personal protection

CONTROL PARAMETERS
OCCUPATIONAL EXPOSURE BAND (OEB):
OEB 3: 10-100 mcg/m3. Materials in an OEB 3 category are considered moderate health hazards. The OEB is a range of airborne concentrations
expressed as an 8-hour Time Weighted Average (8-hr. TWA) and is intended to be used with Industrial Hygiene Risk Assessment to assist with
industrial hygiene sampling and selection of proper controls for worker protection. Consult your site safety and industrial hygiene staff for guidance on
handling and control strategies.

EXPOSURE LIMIT VALUES:
No exposure limits are available for this material.

EXPOSURE CONTROLS
The health hazard risks of handling this material are dependent on many factors, including physical form, duration and frequency of process or task, and
effectiveness of engineering controls. Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness of all
exposure control measures. Exposure controls for normal operating or routine procedures follow a tiered strategy. Engineering controls are the
preferred means of long-term or permanent exposure control. If engineering controls are not feasible, appropriate use of personal protective equipment
(PPE) may be considered as alternative control measures. Exposure controls for non-routine operations must be evaluated and addressed as part of
the site-specific risk assessment.

RECOMMENDED PERSONAL PROTECTIVE EQUIPMENT (PPE):
Body Protection: In small-scale or laboratory operations, lab coats or equivalent protection is required. Disposable Tyvek or other dust impermeable suit should be considered based on procedure or level of exposure. Use of additional PPE such as shoe coverings, gauntlets, hood, or head covering may be necessary. Consult your site safety staff for guidance.
In large-scale or manufacturing operations, disposable Tyvek or other dust impermeable suit is recommended and based on level of exposure. Use of additional PPE such as shoe coverings, gauntlets, hood, or head covering may be necessary. Consult your site safety staff for guidance.

Skin Protection: Gloves that provide an appropriate barrier to the skin are recommended if there is potential for contact with this material. Consult your site safety staff for guidance.

Respiratory Protection: Respiratory protective equipment (RPE) may be required for certain laboratory and large-scale manufacturing tasks if potential airborne breathing zone concentrations of substances exceed the relevant exposure limit(s). Workplace risk assessment should be completed before specifying and implementing RPE usage. Potential exposure points and pathways, task duration and frequency, potential employee contact with the substance, and the ability of the substance to be rendered airborne during specific tasks should be evaluated. Initial and ongoing strategies of quantitative exposure measurement should be obtained as required by the workplace risk assessment. All RPE must conform to local and regional specifications for efficacy and performance. Consult your site or corporate health and safety professional for additional guidance.

Eye Protection: Safety glasses with side shields. Use of goggles or full face protection may be required based on hazard, potential for contact, or level of exposure. Consult your site safety staff for guidance.

Stability and reactivity

STABILITY/ REACTIVITY:
No hazardous reactions known.

CONDITIONS AND MATERIALS TO AVOID:
Exposure to light.

HAZARDOUS DECOMPOSITION PRODUCTS / REACTIONS:
Carbon oxides (COx). Hydrogen fluoride (HF).

Disposal considerations

WASTE TREATMENT METHODS

MATERIAL WASTE:
Disposal must be in accordance with applicable federal, state/provincial, and/or local regulations. Incineration is the preferred method of disposal, when
appropriate. Operations that involve the crushing or shredding of waste materials or returned goods must be handled to meet the recommended
exposure limit(s).

PACKAGING AND CONTAINERS:
Disposal must be in accordance with applicable federal, state/provincial, and/or local regulations.