Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
a short-term toxicity study does not need to be conducted because a reliable sub-chronic (90 days) or chronic toxicity study is available, conducted with an appropriate species, dosage, solvent and route of administration
other:

Data source

Referenceopen allclose all

Title:
No information
Bibliographic source:
ATSDR (1999) U.S. Department of Health and Human Services Toxicological profile for formaldehyde Public Health Service. Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29
Title:
No information
Bibliographic source:
Haneke K (2002) Methylolurea [1000-82-4] Review of Toxicological Literature Integrated Laboratory Systems P.O. Box 13501 Research Triangle Park, North Carolina 27709 http://ntp-server.niehs.nih.gov/ntp/htdocs/Chem_Background/ExSumPdf/ Methylolurea2.pdf
Title:
No information
Bibliographic source:
OECD (1996) Urea, CAS No.: 57-13-6 OECD SIDS (Screening Information Data Set) UNEP Publications
Title:
No information
Bibliographic source:
OECD (2002) Formaldehyde, CAS 50-00-0 SIDS Initial Assessment Report for SIAM 14 UNEP Publication
Title:
No information
Bibliographic source:
Tyl RW, Ballantyne B, Fisher L, Fait D, Dodd D, Klonne D, Pritts I, Losco P (1995a) Evaluation of the developmental toxicity of ethylene glycol aerosol in CD-1 mice by nose-only exposure. Tox Sci 27: 49-62
Title:
No information
Bibliographic source:
Tyl RW, Ballantyne B, Fisher L, Fait D, Savine T, Dodd D, Klonne D, Pritts I (1995b) Evaluation of the developmental toxicity of ethylene glycol aerosol in the CD rat and CD-1 mouse by whole body exposure. Tox Sci 24: 57-75
Title:
No information
Bibliographic source:
US EPA (2002) Urea TRED, Federal Register: April 15, 2002 (Vol. 67, No. 72 http://epa.gov/oppsrrd1/REDs/urea_tred.htm
Title:
No information
Bibliographic source:
WHO (2002) IPCS (International Programme on Chemical Safety) Ethylene Glycol: Human Health Aspects: Concise International Chemical Assessment Document 45 http://www.inchem.org/documents/cicads/cicads/cicad45.htm#7.5

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion